from:
San Francisco
(117.7 miles):

1. Go South on US-101 towards San Mateo, CA, to I-380. 10.1 miles

2. Go Southwest on I-380 to I-280. 2.0 miles

3. Go Southeast on I-280 passing by Palo Alto, CA, to SR-17. 35.2 miles

4. Go South on SR-17 passing by Los Gatos, CA, to SR-1. 24.7 miles

5. Go Southwest on SR-1 passing by Monterey, CA. 45.7 miles

from:
Los Angeles
(330.miles):

1. Go Northeast on Pasadena Freeway to Golden State Freeway (I-5). 1.8 miles

2. Go Northwest on Golden State Freeway (I-5) to I-5 North. 81.2 miles

3. Go North on I-5 North to SR-46 (Exit 282). 59.2 miles

4. Go West on SR-46 to US-101. 65.8 miles

5. Go Northwest on US-101 towards Salinas, CA, to SR-68. 99.1 miles

6. Go Southwest on SR-68 towards Monterey, CA, to SR-1. 17.7 miles

7. Go Southwest on SR-1. 5.7 miles